SKU
RXSOL-60-6604-395
Title
CYSTEAMINE HYDROCHLORIDE for synthesis
Title
CYSTEAMINE HYDROCHLORIDE for synthesis
Synthesis of sup 14/C-cysteamine and cystamine. Bulgaria. The cysteamine hydrochloride compound was obtained by dissolving 100 mg of the cysteamine salicylate in 5 ml of water, acidifying with concentrated hydrochloric acid to a pH of 1 to 2, and extracting with 5 ml of ether five times. Yield is 90 percent.
Field Note
Note
Cysteamine, as a part of CoA plays a crucial role in metabolism by facilitating thioester formation. However, as a free entity, cysteamine is largely absent from metabolism. By contrast, supraphysiological amounts of this simple aminothiol have profound and selective effects of physiology and certain diseases.
Application
Cysteamine is a cystine depleting agent used to treat the effects of cystinosis. Cystinosis is a rare disease caused by mutations in the CTNS gene that encodes for cystinosin, a protein responsible for transporting cystine out of the cell lysosome.
Dose
110 lbs or more:
-Initial dose: 0.3 to 0.5 g/day orally divided in 4 doses. Increase dose gradually over 4 to 6 weeks if the WBC cystine level remains above 2 nmol half-cystine/mg protein.
-Maintenance dose: 2 g/day orally divided in 4 doses
Delayed-release capsule:
-Initial dose: 0.2 to 0.3 g/m2/day orally divided in 2 doses, every 12 hours. Increase dose gradually over 4 to 6 weeks if the WBC cystine level remains above 1 nmol half-cystine/mg protein.
-Maintenance dose: 1.3 g/m2/day orally divided in 2 doses, every 12 hours
Maximum dose: 1.95 g/m2/day
-Maximum dose: 1.95 g/m2/day110 lbs or more:
-Initial dose: 0.3 to 0.5 g/day orally divided in 4 doses. Increase dose gradually over 4 to 6 weeks if the WBC cystine level remains above 2 nmol half-cystine/mg protein.
-Maintenance dose: 2 g/day orally divided in 4 doses
Delayed-release capsule:
-Initial dose: 0.2 to 0.3 g/m2/day orally divided in 2 doses, every 12 hours. Increase dose gradually over 4 to 6 weeks if the WBC cystine level remains above 1 nmol half-cystine/mg protein.
-Maintenance dose: 1.3 g/m2/day orally divided in 2 doses, every 12 hours
-Maximum dose: 1.95 g/m2/day
Locations
[CYSTEAMINE HYDROCHLORIDE for synthesis] manufacturers, suppliers, exporters in Mumbai, Gandhidham, Kolkata, Varanasi, Visakhapatnam, Chennai, Fujairah, Dubai, Canada BC, Barka, Sohar, Muscat, Oman.
Lab chemicals manufacturers, suppliers, exporters in India, UAE Middle East, Barka, Sohar, Muscat, Oman, Canada.
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